Synthesis, Characterization, and Anti??Amoebic Activity of N??(Pyrimidin??2??yl) benzenesulfonamide Derivatives

…, M Arshad, E Ju Lee, S Pokharel, I Choi…

文献索引：Roouf Bhat, Abdul; Arshad, Mohammad; Ju Lee, Eun; Pokharel, Smritee; Choi, Inho; Athar, Fareeda Chemistry and Biodiversity, 2013 , vol. 10, # 12 p. 2267 - 2277

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被引用次数: 3

摘要

Abstract A new series of N-(pyrimidin-2-yl) benzenesulfonamide derivatives, 3a–3i and 4a– 4i, was synthesized from pyrimidin-2-amines, 2a–2i, with the aim to explore their effects on in vitro growth of Entamoeba histolytica. The chemical structures of the compounds were elucidated by elemental analysis, FT-IR, 1 H-and 13 C-NMR, and ESI mass-spectral data. In vitro anti-amoebic activity was evaluated against HM1: IMSS strain of Entamoeba ...