前往化源商城

Il Farmaco

1-PHENYL-lH-INDAZOLE DERIVATIVES WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES

LML SANSEBASTIANO, PFP SCI-IENONE…

文献索引:Mosti; Sansebastiano; Fossa; Schenone; Mattioli Farmaco, 1992 , vol. 47, # 3 p. 357 - 365

全文:HTML全文

被引用次数: 14

摘要

SUMMARY-The synthesis of 4-hydroxy-1-phenyl-lH-indazoleóucetic acid 5 4-melhoxy-1- phenyl-IH-indazole-5-yl-acetic acicl 7 and 5-benzyl-I-phenyl-JH-indazol-4-ol 8, starting from 1, 5, 6, 7-tetrahya'ro-1-phenyl-4H-indazoI-4-one, is described. T hese compouna's sho wed in mice an analgesic activity superior to that of acetylsalicylic acid and comparable to that of dipyrone; moreover, compound 5 exhibited an appreciable anti-inflammatory activity in ...