Tetrahedron

Cyclopentanones—XVI: Prostaglandin synthesis involving catalytic hydrogenation of 2, 3-dialkyl-4-hydroxy-2-cyclopentenones

P De Clercq, R Coen, E Van Hoof, M Vandewalle

文献索引：De Clercq,P. et al. Tetrahedron, 1976 , vol. 32, p. 2747 - 2752

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被引用次数: 15

摘要

2, 3-Dialkyl-4-hydroxy-2-cyclopentenones with differently functionalised side chains yield predominantly all-cis 2, 3-dialkyl-1-4,-dihydroxycyclopentanes on catalytic hydrogenation. Epimerisation at C-12 (PG numbering) leads to prostaglandin synthons. Influence of the side- chain functions on these reactions is described.