Tetrahedron

Synthesis of nitrogen heterocycle-fused 1, 2, 4-benzothiadiazine-1, 1-dioxide, quinazolinone, and pyrrolidinone derivatives with a guanidine joint via sequential aza- …

…, T Sakai, N Kitamura, K Kubokawa, N Kutsumura…

文献索引：Hirota, Shinsuke; Sakai, Terumi; Kitamura, Nobuhide; Kubokawa, Keisuke; Kutsumura, Noriki; Otani, Takashi; Saito, Takao Tetrahedron, 2010 , vol. 66, # 3 p. 653 - 662

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被引用次数: 16

摘要

We achieved efficient synthesis of imidazo-and pyrimido [1, 2-b] benzo-1, 2, 4-thiadiazine-1, 1-dioxides by the tandem aza-Wittig reaction/intramolecular NH-nucleophilic addition/NH- nucleophilic substitution cyclization methodology, involving sulfonamide ester-containing carbodiimides as the key intermediates. Similarly, imidazo [2, 1-b] quinazolinones, imidazo [1, 2-a] pyrimidinediones, and imidazo [1, 2-a] imidazolidinediones were also synthesized ...