Synthesis and binding properties of a macrobicyclic receptor for N-protected peptides with a carboxylic acid terminus
PD Henley, CP Waymark, I Gillies…
文献索引：Henley, Peter D.; Waymark, Christopher P.; Gillies, Iain; Kilburn, Jeremy D. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 6 p. 1021 - 1031
A novel macrobicyclic receptor, 3, has been synthesised by linking together a diaminopyridine with suitable amino acids, followed by a double intramolecular cyclisation of a suitably activated precursor. Macrobicycle 3 features a diamidopyridine unit, designed to serve as a specific binding site for carboxylic acid functionality, at the base of an open, bowl-shaped cavity. Incorporation of additional amide functionality around the rim of the ...
