前往化源商城

2, 4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase

…, I Leal, F Zuccotto, C Boussard, R Brun, SL Croft…

文献索引:Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L.; Yardley, Vanessa; Ruiz Perez, Luis M.; Gonzalez Pacanowska, Dolores; Gilbert, Ian H. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4693 - 4711

全文:HTML全文

被引用次数: 52

摘要

This paper describes the synthesis of 4′-substituted and 3′, 4′-disubstituted 5-benzyl-2, 4-diaminopyrimidines as selective inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were then assayed against the recombinant parasite and human enzymes. Some of the compounds showed good activity. They were also tested against the intact parasites using in vitro assays. Good activity was found against Trypanosoma cruzi, ...

 相关合成线路

~98%

~59%

~%

~%

~49%

~%

~%

~%

~78%

~%

~%

~%

~%

~50%

~%

~%

~91%

~76%

~64%

~%

~%

~82%

~%

~%

~69%

~%

~%

~85%

~%

~%

~50%

~%

~%

~86%

~%

~%

~75%

~%

~%

~%

~75%

~%

~78%

~%

~%

~99%

~%

~%

~56%

~%

~65%

~%

~%

~94%

~%

~%

~%

~%

~%

~34%