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Synthesis and pharmacological properties of pyrazolotriazolopyrimidine derivatives

…, S Guccione, G Romeo, L Monsu'Scolaro…

文献索引:Russo, F; Guccione, S; Romeo, G; Monsu'Scolaro, L; Pucci, S; et al. European Journal of Medicinal Chemistry, 1992 , vol. 27, # 1 p. 73 - 80

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被引用次数: 31

摘要

Abstract As a part of research on anti-inflammatory-analgesic compounds, pyrazolotriazolopyrimidines were prepared by cycling the corresponding 2-phenylamino-3- aminopyrazolo [3, 4-d] pyrimidin-4-one derivatives 3a–h with triethylorthoformate, in the presence of p-toluenesulfonic acid. The results of the pharmacological screening indicate that some of the derivatives which were tested, especially 3c and 6e, showed a good anti- ...

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