Synthesis and SAR study of a novel series of dopamine receptor agonists

…, M Jensen, M Jørgensen, B Bang-Andersen…

文献索引：Risgaard, Rune; Jensen, Martin; Jorgensen, Morten; Bang-Andersen, Benny; Christoffersen, Claus T.; Jensen, Klaus G.; Kristensen, Jesper L.; Pueschl, Ask Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 381 - 392

全文：HTML全文

被引用次数: 3

摘要

Abstract The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D 1 and D 2 receptors. This series was designed from pergolide and (4aR, 10aR)-1-propyl-1, 2, 3, 4, 4a, 5, 10, 10a-octahydro- benzo [g] quinolin-6-ol (PHBQ) and resulted in the synthesis of (2R, 4aR, 10aR)-2- methylsulfanylmethyl-4-propyl-3, 4, 4a, 5, 10, 10a-hexahydro-2H-naphtho [2, 3-b][1, 4] ...