Synthesis of thieno [2, 3??b][1, 5] benzoxazepine derivatives

…, H Tanaka, K Kimura, H Horiuchi, K Seio…

文献索引：Kohara, Toshiyuki; Tanaka, Hiroshi; Kimura, Koreichi; Horiuchi, Hideki; Seio, Kohji; Arita, Masafumi; Fujimoto, Tetsuya; Yamamoto, Iwao Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 1 p. 163 - 171

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被引用次数: 16

摘要

Abstract A new series of 4-(4-methylpiperazin-1-yl) thieno [2, 3-b][1, 5] benzoxazepines 1a-k has been synthesized from 4-bromo-2-methylthiophene 6 or ethyl 2-amino-4, 5-dimethyl-3- thiophencarboxylate 10. Preparation of the key intermediate thieno [2, 3-b][1, 5] benzoxazepine-4 (5H)-ones 4a-i, 4k were carried out by treatment of 2-bromo-N-(2- hydroxyphenyl)-3-thiophencarboxamides 5a-i, 5k with potassium carbonate in DMSO. ...