The Journal of Organic Chemistry

Novel 5-desmethylene analogs of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolic acid as potential anticancer agents

EC Taylor, P Gillespie, M Patel

文献索引：Taylor, Edward C.; Gillespie, Paul; Patel, Mona Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3218 - 3225

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被引用次数: 38

摘要

36, R= R'= H been eliminated by deletion of the methylene group at paition 5. Our target compounds were selected to provide us with data on a range of compounds in which (i) the length and rigidity of the tether were varied and (ii) the lactam functionality in the pyrimidine ring was replaced by imino ether or imidoyl chloride functionalities. For our synthesis of open-chain analogues 18 and 19, we required mesylates 6 and 7 (Chart I). Methyl 4- ...