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Quantitative and site-directed chemical modification of hypocrellins toward direct drug delivery and effective photodynamic activity

H Deng, X Liu, J Xie, R Yin, N Huang…

文献索引:Deng, Hong; Liu, Xin; Xie, Jie; Yin, Rong; Huang, Naiyan; Gu, Ying; Zhao, Jingquan Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1910 - 1919

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被引用次数: 10

摘要

For photodynamic therapy (PDT) treatment of microvascular diseases, drugs are delivered via blood circulation and the targets are vasculature endothelial cells, for which the contradictory requirements of hydrophilicity and lipophilicity of the drugs have been achieved by liposome preparations. Herein, it is demonstrated that the drug delivery and target affinity are achieved by a single chemical compound, hypocrellin B (HB) derivative ...