Mycosamine orientation of amphotericin B controlling interaction with ergosterol: sterol-dependent activity of conformation-restricted derivatives with an amino- …
N Matsumori, Y Sawada, M Murata
文献索引：Matsumori, Nobuaki; Sawada, Yuri; Murata, Michio Journal of the American Chemical Society, 2005 , vol. 127, # 30 p. 10667 - 10675
Amphotericin B (AmB 1) is known to assemble together and form an ion channel across biomembranes. The antibiotic consists of mycosamine and macrolactone moieties, whose relative geometry is speculated to be determinant for the drug's channel activity and sterol selectivity. To better understand the relationship between the amino-sugar orientation and drug's activity, we prepared conformation-restricted derivatives 2-4, in which the amino ...
