Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging

…, W Kraus, HJ Pietzsch, J Kropp…

文献索引：Jung, Christian M.; Kraus, Werner; Leibnitz, Peter; Pietzsch, Hans-Juergen; Kropp, Joachim; Spies, Hartmut European Journal of Inorganic Chemistry, 2002 , # 5 p. 1219 - 1225

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被引用次数: 30

摘要

Technetium-labeled fatty acids intended for myocardial metabolism imaging and the respective rhenium model complexes were synthesized according to the “4+ 1” mixed-ligand approach and investigated in vitro and in vivo. The non-radioactive rhenium model complexes were characterized by NMR, IR, and EA, and the geometrical impact of the chelate unit on the integrity of the fatty acid head structure was determined by single- ...