Synthesis of novel mast cell-stabilising and anti-allergic 1, 2, 3, 4-tetrahydro-1-naphthalenols and related compounds

JW Barlow, AP McHugh, O Woods, JJ Walsh

文献索引：Barlow, James W.; McHugh, Aengus P.; Woods, Orla; Walsh, John J. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1545 - 1554

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被引用次数: 9

摘要

In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C–C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1, 2, 3, 4-tetrahydro-1- naphthalenol 12 exhibited most promising activity both in vitro and in vivo.