A number of possible approaches to the ring-aminated isoproterenol derivative 4-[1-hydroxy- 2-[(l-methyl-ethyl) amino] ethyl]-5-amino-1, 2-benzenediol have been attempted. Of these, the total synthesis using the commercially available starting material 6-nitropiperonal proved to be the optimum route. This compound was first converted to 2-nitrc-4, 5- dihydroxybenzaldehyde and the side chain of the molecule then constructed via ...
