Distance of hydroxyl functionality from the quaternized center influence DNA binding and in vitro gene delivery efficacies of cationic lipids with hydroxyalkyl …

YV Mahidhar, M Rajesh, SS Madhavendra…

文献索引：Mahidhar, Yenugonda Venkata; Rajesh, Mukthavaram; Madhavendra, Sunkara Sakunthala; Chaudhuri, Arabinda Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5721 - 5728

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被引用次数: 7

摘要

In vitro gene delivery efficacies of cationic amphiphiles 1-7 (Scheme 1) were measured by both the reporter gene expression assays in CHO, COS-1, HepG2, and MCF7 cells and by the whole cell histochemical X-gal staining of representative Chinese hamster ovary cells. Our results demonstrated that in vitro gene delivery efficiencies of cationic lipids with hydroxyalkyl headgroups are adversely affected by increased covalent distances between ...