Structure–activity study of novel tricyclic benzazepine arginine vasopressin antagonists

…, J Coupet, X Ru, H Mazandarani, T Saunders

文献索引：Sum, Fuk-Wah; Dusza, John; Delos Santos, Efren; Grosu, George; Reich, Marvin; Du, Xumei; Albright, J. Donald; Chan, Peter; Coupet, Joseph; Ru, Xun; Mazandarani, Hossein; Saunders, Trina Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2195 - 2198

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被引用次数: 26

摘要

Novel tricyclic benzazepine derivatives were synthesized as arginine vasopressin (AVP) antagonists. Several tricyclic compounds showed potent antagonistic activity in rat AVP receptors V1a and V2. Derivatives containing pyrrolo-tricyclic amines, 13i–k, 30, and 31 also showed selectivity for the V2 receptor.