S??Nitrosothiol and Disulfide Formation through Peroxynitrite??Promoted Oxidation of Thiols

…, PC Montevecchi, S Strazzari

文献索引：Grossi, Loris; Montevecchi, Pier Carlo; Strazzari, Samantha European Journal of Organic Chemistry, 2001 , # 1 p. 131 - 135

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被引用次数: 12

摘要

Abstract Peroxynitrite reacts with thiols 1 at acidic pH to give the corresponding S- nitrosothiols 2 and disulfides 3. The formation of nitrosothiols 2, the yield of which is strongly pH-dependent, can be rationalized in terms of acid-catalyzed decomposition of the undissociated HPN, probably through the intermediacy of the protonated form H 2 PN+, leading to a species, X− NO, capable of nitrosating the thiol function. In contrast, the ...