Total synthesis of balanol

KC Nicolaou, ME Bunnage, K Koide

文献索引：Nicolaou; Bunnage; Bunnage, Mark E.; Koide; Koide, Kazunori Journal of the American Chemical Society, 1994 , vol. 116, # 18 p. 8402 - 8403

全文：HTML全文

被引用次数: 108

摘要

The recent isolation and structural elucidation of balanol (1, Figure l),'an unusual metabolite produced by the fungus Verticillium balanoides, represents a significant new development in the quest for effective inhibitors of protein kinase C (PKC). Z PKC-mediated signal transduction is known to lead to a variety of cellular responses, including gene expression and cell proliferation, 2J and activated PKC has been implicated in conditions as diverse ...