Cholinergic agents structurally related to furtrethonium. 2. Synthesis and antimuscarinic activity of a series of N-[5-[(1'-substituted-acetoxy) methyl]-2-furfuryl] …

…, G Gaviraghi, G Toson, M Mor, A Barbieri…

文献索引：Feriani, Aldo; Gaviraghi, Giovanni; Toson, Giancarlo; Mor, Marco; Barbieri, Annalisa; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4278 - 4287

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被引用次数: 15

摘要

In the first part of this study, devoted to the discovery of selective antimuscarinic agents,(&)-N- [5-[(l'-phenyl-l'-cyclohexylacetoxy) methyll-2-~ ll~ ethyl~ e(Sa) proved to be at least 20 times more potent in the rat ileum and bladder than in guinea pig atria.'Several (f)-N-[5-[(l'- substituted-acetoxy) methyll-2-fu~ urylldialkylamine analogs of 5a were subsequently prepared. This involved exploration of the tertiary nitrogen substituents and modulation of ...