Journal of medicinal chemistry

Synthesis and structure-activity relationship study of antidiabetic penta-O-galloyl-D-glucopyranose and its analogues

Y Ren, K Himmeldirk, X Chen

文献索引：Ren, Yulin; Himmeldirk, Klaus; Chen, Xiaozhuo Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2829 - 2837

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被引用次数: 72

摘要

The rapid increase of obesity-associated diabetes has created urgent demands for more effective antidiabetic therapies and pharmaceuticals that are able to address the problems of hyperglycemia and weight gain simultaneously. Our previous studies indicated that the α- and β-anomers of penta-O-galloyl-d-glucopyranose (PGG), 2 and 3, act as insulin mimetics that bind to and activate the insulin receptor, stimulate glucose transport in adipocytes, ...