Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo [b] thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification …
The adherence of neutrophils to vascular endothelium is essential to the pathogenesis of acute inflammation. The initial adherence of the neutrophils is followed by their migration from the vasculature into the surrounding tissue, resulting in tissue damage, swelling, and pain. The steps in this cascade of events are mediated by the interaction of specific cell surface proteins, termed adhesion E-Selectin (ELAM-1, endothelial leukocyte adhesion m ...
