Tetrahedron Letters

Asymmetric total synthesis of (S)-dapoxetine

SJ Kim, TH Jeon, IS Kim, YH Jung

文献索引：Kim, Sun Joo; Jeon, Tae Hong; Min, Im Sook; Kim, In Su; Jung, Young Hoon Tetrahedron Letters, 2012 , vol. 53, # 28 p. 3680 - 3682

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被引用次数: 15

摘要

A concise asymmetric total synthesis of (S)-dapoxetine from commercially available 3- chloropropiophenone is described. The key step includes a highly stereoselective amination of chiral benzylic ether, with the retention of stereochemistry, using chlorosulfonyl isocyanate.