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Total synthesis of lactacystin

EJ Corey, GA Reichard

文献索引：Journal of the American Chemical Society, , vol. 114, # 26 p. 10677 - 10678

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被引用次数: 163

摘要

... Department of Chemistry, Harvard University Cambridge, Massachusetts 021 38 Received September 14, 1992 ... and neuroscience re- search tools3” and the scarcity of 1 encouraged us to undertake the ... 0002-7863/92/1514-10677$03.00/0 0 1992 American Chemical Society ...

METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE结构式

METHYL (2R,3S)-...

~%

(3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE结构式

(3R,4S,5R,6S)-1...

methyl (2R,4R)-3-benzyl-2-tert-butyl-4-[(1S)-1-hydroxy-2-methylpropyl]-1,3-oxazolidine-4-carboxylate结构式

methyl (2R,4R)-...

~%

(3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE结构式

(3R,4S,5R,6S)-1...

(4R,5S)-N-Benzyl-4-(t-butyldimethylsilyloxymethyl)-4-hydroxymethyl-5-isopropyloxazoladine结构式

(4R,5S)-N-Benzy...

~%

(3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE结构式

(3R,4S,5R,6S)-1...

(4R,5S)-3-benzyl-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-isopropyloxazolidine-4-carbaldehyde结构式

(4R,5S)-3-benzy...

~%

(3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE结构式

(3R,4S,5R,6S)-1...

methyl (4R,5S)-3-benzyl-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-propan-2-yl-1,3-oxazolidine-4-carboxylate结构式

methyl (4R,5S)-...

~%

(3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE结构式

(3R,4S,5R,6S)-1...

Total synthesis of lactacystin

[Corey; Reichard, Gregory A. Journal of the American Chemical Society, 1992 , vol. 114, # 26 p. 10677 - 10678]

A new magnesium-catalyzed doubly diastereoselective anti-ald...

[Journal of the American Chemical Society, , vol. 120, # 10 p. 2330 - 2336]