Eighteen analogues of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between the aryl/heteroaryl and tetrahydropyridyl moieties, were better substrates of the enzyme than the conformationally restricted MPTP. It is suggested that the increased oxidative activity of ...
![4-[(E)-2-(3-bromophenyl)ethenyl]-1-methyl-3,6-dihydro-2H-pyridine结构式](https://image.chemsrc.com/caspic/174/141686-03-5.png)
