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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron letters

Synthesis of {1-[2′, 5′-Bis-O-(t-butyldimethylsilyl)-β-d-xylo-and β-d-ribofuranosyl] thymine}-3′-spiro-5 ″-{4 ″-amino-1 ″, 2 ″-oxathiole-2 ″, 2 ″-dioxide}(TSAO). …

MJ Pérez-Pérez, A San-Félix, C María-José…

文献索引：Perez-Perez; San-Felix; Camarasa; Balzarini; De Clercq Tetrahedron Letters, 1992 , vol. 33, # 21 p. 3029 - 3032

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被引用次数: 34

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Reaction of O-mesylcyanohydrins of furanos-3′-ulosyl thymine with bases afforded β-d-xylo- and ribo-3′-substituted nucleosides. 2′-Deoxygenation of the selectively 5′-O-protected nucleoside gave the ribofuranosyl derivative of thymidine. ... DD Richman, MA Fischl, MH ...

1-(2,5-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl)thymine结构式

1-(2,5-bis-O-(t...

~%

[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-cyano-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] methanesulfonate结构式

[(2R,3R,4R,5R)-...

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叔丁基二甲基氯硅烷结构式

叔丁基二甲基氯硅烷

(1-(β-D-ribofuranosyl)thymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide)结构式

(1-(β-D-ribofur...

~83%

1-[(6R,8R,9R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-9-hydroxy-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

~%

1-[(6R,8R,9R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-9-hydroxy-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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1-(2,5-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl)thymine结构式

1-(2,5-bis-O-(t...

~%

1-[(6R,8R,9R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-9-hydroxy-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-cyano-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] methanesulfonate结构式

[(2R,3R,4R,5R)-...

~%

1-[(6R,8R,9R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-9-hydroxy-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-carbonitrile结构式

(2R,4R,5R)-4-((...

~%

1-[(6R,8R,9R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-9-hydroxy-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-cyano-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] methanesulfonate结构式

[(2R,3R,4R,5R)-...

~85%

(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

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1-(2,5-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl)thymine结构式

1-(2,5-bis-O-(t...

~%

(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

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(2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-carbonitrile结构式

(2R,4R,5R)-4-((...

~%

(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

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1-(2,5-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl)thymine结构式

1-(2,5-bis-O-(t...

~%

1-[(6R,8R,9R)-4-amino-9-hydroxy-6-(hydroxymethyl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-carbonitrile结构式

(2R,4R,5R)-4-((...

~%

1-[(6R,8R,9R)-4-amino-9-hydroxy-6-(hydroxymethyl)-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

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(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine结构式

(2',5'-bis-O-(t...

~%

1-[(6R,8R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R)-4-am...

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1-(2,5-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl)thymine结构式

1-(2,5-bis-O-(t...

~%

1-[(6R,8R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R)-4-am...

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[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-cyano-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] methanesulfonate结构式

[(2R,3R,4R,5R)-...

~%

1-[(6R,8R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R)-4-am...

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1-[(6R,8R,9R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-9-hydroxy-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R,9R)-4...

~%

1-[(6R,8R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R)-4-am...

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(1-(β-D-ribofuranosyl)thymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide)结构式

(1-(β-D-ribofur...

~%

1-[(6R,8R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R)-4-am...

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(2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-carbonitrile结构式

(2R,4R,5R)-4-((...

~%

1-[(6R,8R)-4-amino-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2λ6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione结构式

1-[(6R,8R)-4-am...

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Synthesis of {1-[2′, 5′-Bis-O-(t-butyldimethylsilyl)-β-d-xyl...

[Tetrahedron Letters, , vol. 33, # 21 p. 3029 - 3032]

3'-Spiro nucleosides, a new class of specific human immunode...

[Journal of Medicinal Chemistry, , vol. 35, # 15 p. 2721 - 2727]