Synlett

Ionic liquid-an efficient recyclable system for the synthesis of 2, 4-disubstituted quinolines via Meyer-Schuster rearrangement

R Sarma, D Prajapati

文献索引：Sarma, Rupam; Prajapati, Dipak Synlett, 2008 , # 19 p. 3001 - 3005

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被引用次数: 31

摘要

To overcome the problems arising from the addition of stoichiometric amounts of the Brønsted and Lewis acidic or basic reagents, we report herein an efficient and novel synthesis of 2,4-disubstituted quinolines using [hmin]PF 6 as green solvent in presence of catalytic amount of zinc triflate via Meyer-Schuster rearrangement. Accordingly, treatment of 2-amino-5-chloro-2′-fluorobenzophenone (1a) with phenylacetylene (2) in [hmim]PF 6 and in the presence of 1 mol% zinc triflate, ...