The synthesis and antifungal activity of 2-amino-4-aryl-4H, 5H-[1] benzothiopyrano [4, 3-b] pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-[1] benzothiopyrano [4, 3-b] …

…, V Bezjak, S Rashid, B Fullam, MJ Meegan

文献索引：Nakib, T.A.; Bezjak, V.; Rashid, S.; Fullam, B.; Meegan, M.J. European Journal of Medicinal Chemistry, 1991 , vol. 26, # 2 p. 221 - 230

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被引用次数: 27

摘要

Abstract This paper describes the synthesis of a series of 2-amino-4-aryl-4H, 5H-[1] benzothiopyrano [4, 3-b] pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-[1] benzothiopyrano [4, 3-b] pyridine-3-carbonitriles. All of these products were studied for antifungal activity and many of these compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata, and Trichosporon cutaneum.