Asymmetric reduction of ketones by Geotrichum candidum in the presence of Amberlite TM XAD, a solid organic solvent

K Nakamura, M Fujii, Y Ida

文献索引：Nakamura, Kaoru; Fujii, Mikio; Ida, Yoshiteru Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 19 p. 3205 - 3211

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被引用次数: 44

摘要

A hydrophobic polymer, Amberlite™ XAD, was used as material to control the stereochemical course of microbial reductions. In the presence of XAD, simple aliphatic and aromatic ketones were reduced to the corresponding (S)-alcohols in excellent enantiomeric excess (ee) while low enantioselectivities were observed in the absence of the polymer.