Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity towards the muscarinic acetylcholine receptor in a series of pirenzepine and …

…, WW Engel, G Schmidt, H Pelzer, N Mayer

文献索引：Eberlein; Trummlitz; Engel; Schmidt; Pelzer; Mayer Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1378 - 1382

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被引用次数: 37

摘要

The MI-selective antiulcer drug pirenzepine (1) is a tricyclic compound with close resemblance to tricyclic psychotropic agents such as imipramine (2). Despite this fact, pirenzepine is devoid of any psychotropic effects, exhibiting measurable antagonistic effects in biochemical assays and receptor binding studies only toward the muscarinic receptor system. To understand how different groups in these tricyclic molecules affect binding ...