Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

…, P Claes, E De Clercq, P Herdewijn

文献索引：Wigerinck, P.; Snoeck, R.; Claes, P.; Clercq, E. De; Herdewijn, P. Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1767 - 1772

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被引用次数: 36

摘要

Discussion Currently there exists only one electrophilic affmity label for glucocorticoid receptors. This is Dex-Mes, which displays irreversible antiglucocorticoid a~ tivity.'-~ J~ We have now prepared several new potential electrophilic affinity labels which could have irreversible agonist or antagonist activity. One of these, Dex-NCS (6 in (Scheme I) fulfills all of the requirements for being a new affinity label.(1) Dex-NCS has reasonable affinity for ...