Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs

JJ Barchi Jr, VE Marquez, JS Driscoll…

文献索引：Barchi, Joseph J.; Marquez, Victor E.; Driscoll, John S.; Ford, Harry; Mitsuya, Hiroaki; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1647 - 1655

全文：HTML全文

被引用次数: 79

摘要

Selected acid-stable (2'-fluoro-2', 3'-dideoxyarabinofuranosyl) adenine nucleosides containing methyl groups and other lipophilic functions at various positions in the adenine ring were prepared and evaluated as anti-HIV agents. The NB-methyl (If), P-benzoyl (lg), and 6-chloro (li) analcgues had modest activity, giving 3&50% protection to ATH8 cells infected with HIV. 2-Methyl (la), &methyl (lh), and 2fl-dimethyl (le) substitution, as well as M ...