Synthesis and pharmacology of 17-amino-5-α-androstane-3-ol derivatives

…, VI Sladkov, VA Parshin, NI Men'shova…

文献索引：Merlani, M. I.; Sladkov, V. I.; Parshin, V. A.; Men'shova, N. I.; Levina, I. I.; Suvorov, N. N. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 12 p. 950 - 954 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 12 p. 1431 - 1435

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摘要

Steroid hormones acting upon the CNS are known to cause various neuroendoerine and behavioral effects, including sedation and anesthesia [9, 13, 14]. Thus, 3a, 5#- tetrahydrodesoxycorticosterone (3, 5-TNDOS) has exhibited anxiolytie, sedative, and anti- aggressive effects on experimental animals [6, 10]. There have been recent reports about amino steroids whose principal action affects excitation transmission in the spinal cord [8]. ...