Synthetic Communications

Practical and Scalable Synthesis of Ethyl (R)-Piperidine-3-acetate

YG Zhu, HZ Kan, LQ Jiang, WH Hu

文献索引：Zhu, Ying-Guang; Kan, Hong-Zhu; Jiang, Li-Qin; Hu, Wen-Hao Synthetic Communications, 2012 , vol. 42, # 8 p. 1137 - 1145

全文：HTML全文

被引用次数: 2

摘要

A practical and scalable synthesis of ethyl (R)-piperidine-3-acetate was achieved from commercially available 3-pyridylacetic acid in 76% overall yield. The practical synthesis was demonstrated on 100-g scale. One-pot reductive N-ethylation of the pyridinium salt with acetonitrile gave an