Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1, 4-dihydro-6-methyl-2-[(phenylsulfonyl) methyl]-4-aryl-3-pyridinecarboxylate and analogs. …

…, RE Weishaar, RP Steffen, TA Pugsley…

文献索引：Sircar; Gregor; Anderson; Haleen; Shih; Weishaar; Steffen; Pugsley; Taylor Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2248 - 2260

全文：HTML全文

被引用次数: 17

摘要

C-4 protons indicates an orthogonal torsional angle for C-3, 4 protons. Therefore, a trans configuration was as-signed because an orthogonal torsional angle is not accessible to the cis isomer. Only a single geometrical isomer possessing a 2 exocyclic double bond, l3J4 with S-Ar and NH bonds mutually parallel, was isolated except for the bicyclic derivative in which case both 2 and E isomers (118a and 118b) were obtained (see Experimental ...