Synthesis of γ??Oxo γ??Aryl and γ??Aryl α??Amino Acids from Aromatic Aldehydes and Serine

S Chacko, R Ramapanicker

文献索引：Chacko, Shibin; Ramapanicker, Ramesh European Journal of Organic Chemistry, 2012 , # 36 p. 7120 - 7128

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被引用次数: 5

摘要

Abstract γ-Oxo α-amino acids and γ-aryl α-amino acids are compounds with very interesting biological properties and are active components of many drug molecules. Oxo amino acids are also used as synthetic precursors for a number of unnatural amino acids and amino alcohols. We report a very efficient synthesis of such compounds through the coupling of aromatic dithianes, prepared from aromatic aldehydes and an iodide derivative of serine. ...