Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs)

…, I Farre-Gutierrez, N Garton, T Hayhow, G Hutley…

文献索引：Panchal, Terry; Bailey, Nick; Bamford, Mark; Demont, Emmanuel; Elliott, Richard; Farre-Gutierrez, Irene; Garton, Neil; Hayhow, Thomas; Hutley, Gail; Naylor, Antoinette Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6813 - 6817

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被引用次数: 9

摘要

A variety of basic, heterocyclic templates has been reported as potassium-competitive, acid pump antagonists. Herein, we report a comparison of potencies of these templates and others to establish which offers the best start point for further systematic optimisation. Modifications were carried out to improve the developability profile of the more potent 1H- pyrrolo [2, 3-c] pyridine template, affording molecules with improved overall in vitro ...