Photochemical gating of intracellular Ca2+ release channels

…, DA Auston, DA Freilich, S Muralidharan…

文献索引：Ni, Jiahong; Auston, Darryl A.; Freilich, David A.; Muralidharan, Sukumaran; Sobie, Eric A.; Kao, Joseph P. Y. Journal of the American Chemical Society, 2007 , vol. 129, # 17 p. 5316 - 5317

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被引用次数: 11

摘要

We have synthesized BiNiX, a caged methylxanthine agonist for the ryanodine receptor (RyR) the major calcium channel that mediates Ca2+ release from intracellular Ca2+ stores in electrically excitable cells. BiNiX is easily loaded into living cells through incubation with its acetoxymethyl (AM) ester. Delivery of focused UV light pulses to the loaded cell releases paraxanthine focally and rapidly to activate RyRs to release Ca2+, thus elevating ...