New 4-(heteroanilido) piperidines, structurally related to the pure opioidagonist fentanyl, with agonist and/or antagonist properties

…, BM Doorley, HK Spencer, T Spaulding

文献索引：Bagley; Wynn; Rudo; Doorley; Spencer; Spaulding Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 663 - 671

全文：HTML全文

被引用次数: 53

摘要

A research program based on certain heterocyclic modifications (12-50) of the fentanyl (1) molecule has generated a novel class of opioids. In the mouse hot-plate test, these compounds were weaker analgesics than 1. Two types of antagonists were observed in morphine-treated rabbits: those (eg, 28) that reversed both respiratory depression and analgesia and those (eg 32) that selectively reversed respiratory depression. Evaluation ...