Derivatives of 2-(dipropylamino) tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors

…, BE Svensson, L Cortizo, T Lewander…

文献索引：Liu; Yu; Svensson; Cortizo; Lewander; Hacksell Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4221 - 4229

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被引用次数: 35

摘要

A series of 2-(dipropy1amino) tetralin derivatives in which the C8 substituent is varied has been prepared and evaluated pharmacologically to explore the importance of the C8 substituent in the interaction of 2-aminotetralin-based ligands with serotonin (5-HTd receptors. Enantiopure derivatives were prepared by facile palladium-catalyzed reactions of the triflates of the enantiomers of 8-hydroxy-2-(dipropylamino) tetralin (gOH-DPAT, 1). The ...