Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation

…, L Strekowski, FA Tanious, RA Watson…

文献索引：Wilson, D. David; Strekowski, Lucjan; Tanious, Farial A.; Watson, Rebecca A.; Mokrosz, Jerzy L.; et al. Journal of the American Chemical Society, 1988 , vol. 110, # 24 p. 8292 - 8299

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被引用次数: 53

摘要

Abstract: A new type of intercalator, 1, and its nonintercalating analogue, 2, are both twisted about the torsional bonds joining the aromatic rings. Spectroscopic methods and MM2 calculations indicate that the twist for 2 is significantly greater than for 1 (48O versus 25'from MM2) in solution. X-ray crystallographic analysis indicates that the torsional angles are loo and 19O for the two phenyl-pyrimidine plane intersections in 1. The DNA binding constant ...