Evaluation of a brain-targeting zidovudine chemical delivery system in dogs.

…, D Moreno, H Derendorf, N Bodor, E Pop

文献索引：Brewster, Marcus E.; Anderson, Wesley R.; Webb, Alistair I.; Pablo, Luisito M.; Meinsma, Donald; Moreno, Dan; Derendorf, Hartmut; Bodor, Nicholas; Pop, Emil Antimicrobial Agents and Chemotherapy, 1997 , vol. 41, # 1 p. 122 - 128

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被引用次数: 44

摘要

ABSTRACT AIDS encephalopathy is an insidious complication of human immunodeficiency virus infection which is difficult to treat because of the poor uptake of many potentially useful antiretroviral drugs through the blood-brain barrier. A chemical delivery system (CDS) for zidovudine (AZT) based on redox trapping within the brain has been prepared and tested in several animal models to circumvent this limitation. The behavior of the AZT-CDS in the ...