3′-Bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of Mycobacterium tuberculosis

…, N Desroches, B Agrawal, DY Kunimoto…

文献索引：Shakya, Neeraj; Srivastav, Naveen C.; Desroches, Nancy; Agrawal, Babita; Kunimoto, Dennis Y.; Kumar, Rakesh Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4130 - 4140

全文：HTML全文

被引用次数: 18

摘要

Tuberculosis (TB) is a major health problem worldwide. We herein report a new class of pyrimidine nucleosides as potent inhibitors of Mycobacterium tuberculosis (M. tuberculosis). Various 2′-or 3′-halogeno derivatives of pyrimidine nucleosides containing uracil, 5- fluorouracil, and thymine bases were synthesized and evaluated for antimycobacterial activities. Among the compounds tested, 3′-bromo-3′-deoxy-arabinofuranosylthymine ( ...