Synthesis of trifluoromethylated pyrazine-containing nitrogen heterocycles from trifluoropyruvaldehyde and ortho-diamines: scope and regiochemistry

M Cushman, H Patel, A McKenzie

文献索引：Cushman, Mark; Patel, Hemantkumar; McKenzie, Ann Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5088 - 5092

全文：HTML全文

被引用次数: 18

摘要

The structures of the reaction products obtained from the condensation of trifluoropyruvaldehyde with a variety of ortho-diamines have been investigated in order to determine the scope of the reaction and also to investigate which of the structural isomers is formed in larger amount in cases in which two products are possible. As a result of intensive I3C, leF, and'H NMR studies, as well as X-ray analysis, it has been observed that in ...