Structure–activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells

…, CL Fumero-Oderda, SD Kuduk, Z Ma, F Kirikae…

文献索引：Ojima, Iwao; Fumero-Oderda, Cecilia L.; Kuduk, Scott D.; Ma, Zhuping; Kirikae, Fumiko; Kirikae, Teruo Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2867 - 2888

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被引用次数: 17

摘要

A series of new taxoids modified at the C-3′, C-3′ N, C-10, C-2 and C-7 positions has been designed, synthesized and evaluated for their potency to induce NO and TNF production by peritoneal murine macrophages (Mφ) from LPS-responsive C3H/HeN and LPS-hyporesponsive C3H/HeJ strains and human blood cells, and for their ability to inhibit the growth of Mφ-like cell lines J774. 1 and J7. DEF3. The SAR-study has shown that the ...