Synthesis and evaluation of boronic acids as inhibitors of penicillin binding proteins of classes A, B and C

A Zervosen, A Bouillez, A Herman, A Amoroso…

文献索引：Zervosen, Astrid; Bouillez, Andre; Herman, Alexandre; Amoroso, Ana; Joris, Bernard; Sauvage, Eric; Charlier, Paulette; Luxen, Andre Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3915 - 3924

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被引用次数: 20

摘要

In response to the widespread use of β-lactam antibiotics bacteria have evolved drug resistance mechanisms that include the production of resistant Penicillin Binding Proteins (PBPs). Boronic acids are potent β-lactamase inhibitors and have been shown to display some specificity for soluble transpeptidases and PBPs, but their potential as inhibitors of the latter enzymes is yet to be widely explored. Recently, a (2, 6-dimethoxybenzamido) ...