Synthesis and structure-activity relationship of methyl-substituted indolo [2, 3-b] quinolines: novel cytotoxic, DNA topoisomerase II inhibitors

W Peczynska-Czoch, F Pognan…

文献索引：Peczynska-Czoch; Pognan; Kaczmarek; Boratynski Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3503 - 3510

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被引用次数: 163

摘要

In furtherance of our SAR study on the chemistry and antitumor activity of fused nitrogen heteroaromatic compounds, a series of linear, methyl-substituted derivatives of 5H-and 6H- indolo [2, 3-blquinolines were synthesized according to the modified Graebe-Ullmann reaction. To establish the relationship between the physicochemical and biological activities of indolo-[2, 3-blquinolines, their lipophilic properties, cytotoxic and antimicrobial activity, ...