Tetrahedron letters

Kinetic resolution in the directed hydrogenation of N-substituted α-(aminoalkyl) acrylates, precursors of optically active β-amino acids.

JM Brown, AP James, LM Prior

文献索引：Brown, John M.; James, Alun P.; Prior, Louise M. Tetrahedron Letters, 1987 , vol. 28, # 19 p. 2179 - 2182

全文：HTML全文

被引用次数: 44

摘要

... JM Brown, AP James; J. Chem. Soc. (1987), p. 181 Chem. Commun. ... Methyl 2-Hydroxymethyl acrylate (A, R = H) is hydrogenated in 71% ee with catalyst C in MeOH, accompanied by substantial isomerisation to MeCO 2 CHMeCHO; AP James, unpublished work; dimethyl itaconate (B, R = H) is reduced in 88% ee under similar conditions, J. Amer. Chem. Soc., 101 (1979), p. 4408. 4; ... Hsiao, M. Kitamura, T. Ohta, H. Takaya; J. Amer. Chem. Soc., 108 (1986), p. 7117 ...