Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D2 synthases

…, L Labzin, GT Bourne, H Fukunishi…

文献索引：Christ, Angelika N.; Labzin, Larisa; Bourne, Gregory T.; Fukunishi, Hirotada; Weber, Jane E.; Sweet, Matthew J.; Smythe, Mark L.; Flanagan, Jack U. Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5536 - 5548

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被引用次数: 10

摘要

The hematopoietic prostaglandin D2 synthase has a proinflammatory effect in a range of diseases, including allergic asthma, where its product prostaglandin D2 (PGD2) has a role in regulating many of the hallmark disease characteristics. Here we describe the development and characterization of a novel series of hematopoietic prostaglandin D2 synthase inhibitors with potency similar to that of known inhibitors. Compounds N- ...