Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives

…, H Koike, Y Iijima, K Oizumi, Y Matsushita…

文献索引：Yanagisawa; Ishihara; Ando; Kanazaki; Miyamoto; Koike; Iijima; Oizumi; Matsushita; Hata Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 422 - 428

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被引用次数: 42

摘要

Chemical Research Laboratories, Sankyo Co., Ltd., Hiromachi, Shinagawa, Tokyo 140, Japan. Received August 11, 1987 a-[(3S)-3-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl] amino]- 2-oxo-6 or 7-phenylperhydroazepin-l-yl] acetic acids (monoester monoacids) and their dicarboxylic acids were synthesized, and their angiotensin-converting enzyme (ACE) inhibitory activities were evaluated. The dicarboxylic acids having phenyl substituents at ...